My most used apps: Phone, Messages, Mail and Calendar. There are probably 3 other apps I could easily switch out with Calendar (FeedlerRSS, RTM or Camera), but it's what I have now.
Generally, all the apps I use a lot are one tap away. I then have 3 folders full of all the social media apps I can't live without. :) I also like having the Camera in the upper right corner - it just feels right.
I used to have other mini-clusters the Photos-Instagram-Camera (like Facebook-Twitter-FeedlerRSS), but that's recently been lost.
The land of semi-wanted apps. I put everything else into a folder. I'm not sure what I'm going to do once one of these fills up. Break the folder into 2 groups? Not sure, but for now it's working nicely.
I actually use the Reminders app regularly, but it's all using Siri, so it can hide on the second page. I also use the Music app regularly, but a quick double tap of the Home button and left swipe reveals the app and it's controls - so it too can hide in the A / V (Audio / Video) folder.
I also like to put stand alone apps along the left-hand side. Before folders, each left hand column was important, but folders makes that less necessary. I still think it looks more esthetically pleasing.
This is my games page, which is in need of at least another folder (Sports and... something...). The iPhone is a fantastic gaming device and the GameChannel app promotes a couple paid apps, for free, each the day.
I think I've totally re-arranged my games page 3 times since October, so this is definitely something I'm still figuring out.
I only show the weather widget. I don't show up-coming calendar events or new email (that's way too much info). I also turn off almost all badges, and all my alerts are banner.